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Article

Rational design of a mutation to investigate the role of the brain protein TRIP8b in limiting the cAMP response of HCN channels in neurons.

The Journal of general physiology - 7 Sept 2020

Porro Alessandro, Binda Anna, Pisoni Matteo, Donadoni Chiara, Rivolta Ilaria, Saponaro Andrea

Abstract excerpt

TRIP8b (tetratricopeptide repeat-containing Rab8b-interacting protein) is the neuronal regulatory subunit of HCN channels, a family of voltage-dependent cation channels also modulated by direct cAMP binding. TRIP8b interacts with the C-terminal region of HCN channels and controls both channel trafficking and gating. The association of HCN channels with TRIP8b is required for the correct expression and subcellular...

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Identifiers

PMID: 32633755
DOI: 10.1085/jgp.202012596
PMCID: PMC7478871

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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