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Article

Functional characterization of a single nucleotide polymorphism associated with Alzheimer's disease in a hiPSC-based neuron model.

PloS one - 1 Jan 2023

Stolzenburg Lindsay R, Esmaeeli Sahar, Kulkarni Ameya S, Murphy Erin, Kwon Taekyung, Preiss Christina, Bahnassawy Lamiaa, Stender Joshua D, Manos Justine D, Reinhardt Peter, Rahimov Fedik, Waring Jeffrey F, Ramathal Cyril Y

Abstract excerpt

Neurodegenerative diseases encompass a group of debilitating conditions resulting from progressive nerve cell death. Of these, Alzheimer's disease (AD) occurs most frequently, but is currently incurable and has limited treatment success. Late onset AD, the most common form, is highly heritable but is caused by a combination of non-genetic risk factors and many low-effect genetic variants whose disease-causing...

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Identifiers

PMID: 37751459
DOI: 10.1371/journal.pone.0291029
PMCID: PMC10521995

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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