Article
A Significant Regulatory Mutation Burden at a High-Affinity Position of the CTCF Motif in Gastrointestinal Cancers.
Human mutation - 1 Sept 2016
Umer Husen M, Cavalli Marco, Dabrowski Michal J, Diamanti Klev, Kruczyk Marcin, Pan Gang, Komorowski Jan, Wadelius Claes
Abstract excerpt
Somatic mutations drive cancer and there are established ways to study those in coding sequences. It has been shown that some regulatory mutations are over-represented in cancer. We develop a new strategy to find putative regulatory mutations based on experimentally established motifs for transcription factors (TFs). In total, we find 1,552 candidate regulatory mutations predicted to significantly reduce binding...
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