Article

CTCF Binding Site Mutations: Linking Topologically Associated Domains Dysregulation to Cutaneous Squamous Cell Carcinoma Progression

2025-06-24

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold> Cutaneous squamous cell carcinoma (cSCC) is the most common lethal malignancy with metastatic potential. The high mutational burden in cSCC has made it difficult to understand the significance of variants in the noncoding and regulatory genome. This study presents the first investigation<bold> </bold>of mutations at CCCTC-binding factor binding sites (CTCFbs) of...

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Literature Corpus work: 2b4a3c8f-fc17-59d0-ae53-3d4ce9f18d7d
DOI: 10.21203/rs.3.rs-6844715/v1

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