Article

Genetic mapping of multiple metabolic traits identifies novel genes for adiposity, lipids and insulin secretory capacity in outbred rats

2022-03-14

Abstract excerpt

Despite the successes of human genome-wide association studies, the causal genes underlying most metabolic traits remain unclear. We used outbred heterogeneous stock (HS) rats, coupled with expression data and mediation analysis, to identify quantitative trait loci (QTLs) and candidate gene mediators for adiposity, glucose tolerance, serum lipids and other metabolic traits. Physiological traits were measured in 15...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e77ec7c1-2504-5187-bdc4-e4f4b1fa1e51
DOI: 10.1101/2022.03.14.484225

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genetic mapping of multiple metabolic traits identifies novel genes for adiposity, lipids and insulin secretory capacity in outbred ratsDOI 10.1101/2022.03.14.484225Read

Genetic Mapping of Multiple Traits Identifies Novel Genes for Adiposity, Lipids, and Insulin Secretory Capacity in Outbred Rats.Semantic proximity Read

Genetic Fine-Mapping and Identification of Candidate Genes and Variants for Adiposity Traits in Outbred Rats.Semantic proximity Read

Transcriptome-wide Analyses of Adipose Tissue in Outbred Rats Reveal Genetic Regulatory Mechanisms Relevant for Human ObesitySemantic proximity Read

Genome-Wide Association Study in 3,173 Outbred Rats Identifies Multiple Loci for Body Weight, Adiposity, and Fasting Glucose.Semantic proximity Read

Identification of novel candidate neural genes for diet-induced obesity in outbred heterogeneous stock ratsSemantic proximity Read

Genome wide association study in 3,173 outbred rats identifies multiple loci for body weight, adiposity, and fasting glucoseSemantic proximity Read

Conserved properties of genetic architecture of renal and fat transcriptomes in rat models of insulin resistanceSemantic proximity Read

Integrative functional genomics and fine-mapping identify regulatory mechanisms of multivariate obesity GWAS and its cardiometabolic implications.Semantic proximity Read

Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks.Semantic proximity Read

Obesity-insulin targeted genes in the 3p26-25 region in human studies and LG/J and SM/J mice.Semantic proximity Read

Identification of a novel gene for diabetic traits in rats, mice, and humans.Semantic proximity Read

Systems biology with high-throughput sequencing reveals genetic mechanisms underlying the metabolic syndrome in the Lyon hypertensive rat.Semantic proximity Read