Genome-Wide Association Study in 3,173 Outbred Rats Identifies Multiple Loci for Body Weight, Adiposity, and Fasting Glucose.

doi:10.1002/oby.22927

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Genome-Wide Association Study in 3,173 Outbred Rats Identifies Multiple Loci for Body Weight, Adiposity, and Fasting Glucose.

Obesity (Silver Spring, Md.) - 1 Oct 2020

Chitre Apurva S, Polesskaya Oksana, Holl Katie, Gao Jianjun, Cheng Riyan, Bimschleger Hannah, Garcia Martinez Angel, George Tony, Gileta Alexander F, Han Wenyan, Horvath Aidan, Hughson Alesa, Ishiwari Keita, King Christopher P, Lamparelli Alexander, Versaggi Cassandra L, Martin Connor, St Pierre Celine L, Tripi Jordan A, Wang Tengfei, Chen Hao, Flagel Shelly B, Meyer Paul, Richards Jerry, Robinson Terry E, Palmer Abraham A, Solberg Woods Leah C

Abstract excerpt

OBJECTIVE: Obesity is influenced by genetic and environmental factors. Despite the success of human genome-wide association studies, the specific genes that confer obesity remain largely unknown. The objective of this study was to use outbred rats to identify the genetic loci underlying obesity and related morphometric and metabolic traits. METHODS: This study measured obesity-relevant traits, including body...

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PMID: 32860487
DOI: 10.1002/oby.22927
PMCID: PMC7511439

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