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Article

Conserved properties of genetic architecture of renal and fat transcriptomes in rat models of insulin resistance

17 Jun 2019

Abstract excerpt

ABSTRACT To define renal molecular mechanisms that are affected by permanent hyperglycaemia and might promote phenotypes relevant to diabetic nephropathy, we carried out linkage analysis of genome-wide gene transcription in the kidneys of F2 offspring from the Goto-Kakizaki (GK) rat model of type 2 diabetes and normoglycaemic Brown Norway (BN) rats. We mapped 2526 statistically significant expression quantitative...

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PMID: 31213483
DOI: 10.1242/dmm.038539

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