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Article

Systems biology with high-throughput sequencing reveals genetic mechanisms underlying the metabolic syndrome in the Lyon hypertensive rat.

Circulation. Cardiovascular genetics - 1 Apr 2015

Wang Jinkai, Ma Man Chun John, Mennie Amanda K, Pettus Janette M, Xu Yang, Lin Lan, Traxler Matthew G, Jakoubek Jessica, Atanur Santosh S, Aitman Timothy J, Xing Yi, Kwitek Anne E

Abstract excerpt

BACKGROUND: The metabolic syndrome (MetS) is a collection of co-occurring complex disorders including obesity, hypertension, dyslipidemia, and insulin resistance. The Lyon hypertensive and Lyon normotensive rats are models of MetS sensitivity and resistance, respectively. To identify genetic determinants and mechanisms underlying MetS, an F2 intercross between Lyon hypertensive and Lyon normotensive was...

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Share to Chromosomes, Mammalian
Share to Hypertension

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Polymorphism, Single Nucleotide

Share to Quantitative Trait Loci

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Source

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Identifiers

PMID: 25573024
DOI: 10.1161/CIRCGENETICS.114.000520
PMCID: PMC4406788

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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