Article
Genetic Mapping of Multiple Traits Identifies Novel Genes for Adiposity, Lipids, and Insulin Secretory Capacity in Outbred Rats.
Diabetes - 1 Jan 2023
Hong-Le Thu, Crouse Wesley L, Keele Gregory R, Holl Katie, Seshie Osborne, Tschannen Michael, Craddock Ann, Das Swapan K, Szalanczy Alexandria M, McDonald Bailey, Grzybowski Michael, Klotz Jason, Sharma Neeraj K, Geurts Aron M, Key Chia-Chi Chuang, Hawkins Gregory, Valdar William, Mott Richard, Solberg Woods Leah C
Abstract excerpt
Despite the successes of human genome-wide association studies, the causal genes underlying most metabolic traits remain unclear. We used outbred heterogeneous stock (HS) rats, coupled with expression data and mediation analysis, to identify quantitative trait loci (QTLs) and candidate gene mediators for adiposity, glucose tolerance, serum lipids, and other metabolic traits. Physiological traits were measured in...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.