Article
Identification of a novel gene for diabetic traits in rats, mice, and humans.
Genetics - 1 Sept 2014
Tsaih Shirng-Wern, Holl Katie, Jia Shuang, Kaldunski Mary, Tschannen Michael, He Hong, Andrae Jaime Wendt, Li Shun-Hua, Stoddard Alex, Wiederhold Andrew, Parrington John, Ruas da Silva Margarida, Galione Antony, Meigs James, Hoffmann Raymond G, Simpson Pippa, Jacob Howard, Hessner Martin, Solberg Woods Leah C
Abstract excerpt
The genetic basis of type 2 diabetes remains incompletely defined despite the use of multiple genetic strategies. Multiparental populations such as heterogeneous stocks (HS) facilitate gene discovery by allowing fine mapping to only a few megabases, significantly decreasing the number of potential candidate genes compared to traditional mapping strategies. In the present work, we employed expression and sequence...
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