Article
Genetic Fine-Mapping and Identification of Candidate Genes and Variants for Adiposity Traits in Outbred Rats.
Obesity (Silver Spring, Md.) - 1 Jan 2018
Keele Gregory R, Prokop Jeremy W, He Hong, Holl Katie, Littrell John, Deal Aaron, Francic Sanja, Cui Leilei, Gatti Daniel M, Broman Karl W, Tschannen Michael, Tsaih Shirng-Wern, Zagloul Maie, Kim Yunjung, Baur Brittany, Fox Joseph, Robinson Melanie, Levy Shawn, Flister Michael J, Mott Richard, Valdar William, Solberg Woods Leah C
Abstract excerpt
OBJECTIVE: Obesity is a major risk factor for multiple diseases and is in part heritable, yet the majority of causative genetic variants that drive excessive adiposity remain unknown. Here, outbred heterogeneous stock (HS) rats were used in controlled environmental conditions to fine-map novel genetic modifiers of adiposity. METHODS: Body weight and visceral fat pad weights were measured in male HS rats that were...
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