Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inhibitory Roles of Apolipoprotein E Christchurch Astrocytes in Curbing Tau Propagation Using Human Pluripotent Stem Cell-Derived Models

22 Apr 2024

Abstract excerpt

Genetic variants in the apolipoprotein E ( APOE ) gene affect the onset and progression of Alzheimer's disease (AD). The APOE Christchurch ( APOE Ch) variant has been identified as the most prominent candidate for preventing the onset and progression of AD. In this study, we generated isogenic APOE3 Ch/ 3 Ch human-induced pluripotent stem cells (iPSCs) from APOE3 / 3 healthy control female iPSCs and induced them...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Neuroscience and Neuropharmacology Research
Share to Nuclear Receptors and Signaling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 38649269
DOI: 10.1523/jneurosci.1709-23.2024

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inhibitory Roles of Apolipoprotein E Christchurch Astrocytes in Curbing Tau Propagation Using Human Pluripotent Stem Cell-Derived ModelsPMID 38649269Read ↗

APOE ε4/ε4 diminishes neurotrophic function of human iPSC-derived astrocytes.Semantic proximity Read ↗

Astrocytic APOE4 genotype-mediated negative impacts on synaptic architecture in human pluripotent stem cell model.Semantic proximity Read ↗

Chimeric cerebral organoids reveal the essentials of neuronal and astrocytic APOE4 for Alzheimer’s tau pathologySemantic proximity Read ↗

ApoE4-carrying Human Astrocytes Oversupply Cholesterol into Neurons and Promote Aβ GenerationSemantic proximity Read ↗

Divergent Effects of <i>APOE3</i> and <i>APOE4</i> Human Astrocytes on Key Alzheimer’s Disease Hallmarks in Chimeric MiceSemantic proximity Read ↗

PSEN1 Mutant iPSC-Derived Model Reveals Severe Astrocyte Pathology in Alzheimer's DiseaseSemantic proximity Read ↗

Protective mechanisms against Alzheimer’s Disease in APOE3-Christchurch homozygous astrocytesSemantic proximity Read ↗

Differential Signaling Mediated by ApoE2, ApoE3, and ApoE4 in Human Neurons Parallels Alzheimer's Disease RiskSemantic proximity Read ↗

Cholesterol Dysregulation in APOE4 Astrocytes Promotes α-Synuclein Pathology in miBrains, a Human Brain Tissue ModelSemantic proximity Read ↗

APOE2, E3, and E4 differentially modulate cellular homeostasis, cholesterol metabolism, and inflammatory response in isogenic iPSC-derived astrocytes.Semantic proximity Read ↗

An efficient platform for astrocyte differentiation from human induced pluripotent stem cellsSemantic proximity Read ↗

APOE2 mitigates disease-related phenotypes in an isogenic hiPSC-based model of Alzheimer's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.