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Article

APOE2 mitigates disease-related phenotypes in an isogenic hiPSC-based model of Alzheimer's disease.

Molecular psychiatry - 1 Oct 2021

Brookhouser Nicholas, Raman Sreedevi, Frisch Carlye, Srinivasan Gayathri, Brafman David A

Abstract excerpt

Genome-wide association studies (GWAS) have identified polymorphism in the Apolipoprotein E gene (APOE) to be the most prominent risk factor for Alzheimer's disease (AD). Compared to individuals homozygous for the APOE3 variant, individuals with the APOE4 variant have a significantly elevated risk of AD. On the other hand, longitudinal studies have shown that the presence of the APOE2 variant reduces the lifetime...

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Identifiers

PMID: 33837271
DOI: 10.1038/s41380-021-01076-3
PMCID: PMC8501163

Genes

APOE
APP

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APOE2 mitigates disease-related phenotypes in an isogenic hiPSC-based model of Alzheimer's disease.PMID 33837271Read ↗

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