Article

Tarloxotinib targets tumor hypoxia to improve therapeutic efficacy of immune checkpoint inhibition in a TLR9 dependent manner

2025-02-26

Abstract excerpt

<h4>ABSTRACT</h4> Immune checkpoint inhibitors can elicit deep and durable immune responses although most cancer patients fail to experience long-term remission. There is consensus that tumor hypoxia coordinates a multitude of underlying resistance mechanisms that contribute to treatment failure. Here we show that the clinical-stage hypoxia-activated prodrug tarloxotinib lowers tumor hypoxia 8-fold in the EGFR-de...

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Literature Corpus work: e770401a-439e-5506-8472-7fddcb8a3436
DOI: 10.1101/2025.02.24.635378

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