Article

Modified Hypoxia Inducible Factor expression in CD8+ T cells increases anti-tumor efficacy

2020-06-19

Abstract excerpt

Adoptive transfer of anti-tumor cytotoxic T cells is a novel form of cancer immunotherapy, and a key challenge is to ensure the survival and function of the transferred T cells. Immune cell survival requires adaptation to different micro-environments, and particularly to the hypoxic milieu of solid tumors. The HIF transcription factors are an essential aspect of this adaptation, and we undertook experiments to def...

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Literature Corpus work: 0dbfa084-731e-5fed-a134-da97854654fa
DOI: 10.1101/2020.06.18.159137

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