Article

Therapeutic Blockade of Type 2 Cytokines and PD1 Unleashes Anti-Tumor Immunity Through Coordinated Reprogramming of Innate and Adaptive Immune Surveillance

2025-09-29

Abstract excerpt

<h4>Background</h4> Checkpoint inhibitors improve survival in patients with several types of tumors. However, resistance to checkpoint inhibitors creates an opportunity for patients to benefit from novel immunotherapies. The type 2 cytokines IL-4, IL-13 and TSLP have been implicated in suppressing anti-tumor immune responses through T and myeloid cells. Our current study tested whether combined therapeutic blocka...

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Literature Corpus work: aaf92f6d-081a-5317-9cc0-ec802f2c065c
DOI: 10.1101/2025.09.26.678820

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