Article

Serotonin, Etonogestrel and breathing activity in murine Congenital Central Hypoventilation Syndrome

2022-04-19

Abstract excerpt

<h4>ABSTRACT</h4> Congenital Central Hypoventilation Syndrome, a rare disease caused by PHOX2B mutation, is associated with absent or blunted CO 2 /H + chemosensitivity due to the dysfunction of PHOX2B neurons of the retrotrapezoid nucleus. No pharmacological treatment is available. Clinical observations have reported non-systematic CO 2 /H + chemosensitivity recovery under desogestrel. Here, we used a precl...

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Literature Corpus work: e76be6f2-86d2-5f85-829e-aba1a971c268
DOI: 10.1101/2022.04.19.488470

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