Article

Knockdown of PHOX2B in the retrotrapezoid nucleus reduces the central CO <sub>2</sub> chemoreflex in rats

2023-12-14

Abstract excerpt

<h4>ABSTRACT</h4> PHOX2B is a transcription factor essential for the development of the autonomic nervous system. Heterozygous mutations in the PHOX2B coding region are responsible for the occurrence of Congenital Central Hypoventilation Syndrome (CCHS), a rare neurological disorder characterised by inadequate chemosensitivity and life-threatening sleep-related hypoventilation. Animal studies suggest that chemore...

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Literature Corpus work: dd971ed6-322d-5813-9b62-01f22bdad611
DOI: 10.1101/2023.12.13.571591

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