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<i>Phox2b</i> mutation mediated by <i>Atoh1</i> expression impaired respiratory rhythm and ventilatory responses to hypoxia and hypercapnia

2021-08-10

Abstract excerpt

Retrotrapezoid nucleus (RTN) neurons are involved in central chemoreception and respiratory control. Lineage tracing studies demonstrate RTN neurons to be derived from Phox2b and Atoh1 expressing progenitor cells in rhombere 4. Phox2b exon 3 mutations cause congenital central hypoventilation syndrome (CCHS), producing an impaired respiratory response to hypercapnia and hypoxia. Our goal was to investigate the e...

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Literature Corpus work
ff93e5ca-f971-5100-9d42-a3a6e0cf5654
DOI
10.1101/2021.08.09.455641
Open publication

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<i>Phox2b</i> mutation mediated by <i>Atoh1</i> expression impaired respiratory rhythm and ventilatory responses to hypoxia and hypercapniaDOI 10.1101/2021.08.09.455641
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