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Article

Respiratory and autonomic dysfunction in congenital central hypoventilation syndrome

26 May 2016

Abstract excerpt

The developmental lineage of the PHOX2B-expressing neurons in the retrotrapezoid nucleus (RTN) has been extensively studied. These cells are thought to function as central respiratory chemoreceptors, i.e., the mechanism by which brain Pco2 regulates breathing. The molecular and cellular basis of central respiratory chemoreception is based on the detection of CO2 via intrinsic proton receptors (TASK-2, GPR4) as...

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PMID: 27226447
DOI: 10.1152/jn.00026.2016

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