Article
A human mutation in Phox2b causes lack of CO2 chemosensitivity, fatal central apnea, and specific loss of parafacial neurons.
Proceedings of the National Academy of Sciences of the United States of America - 22 Jan 2008
Dubreuil Véronique, Ramanantsoa Nélina, Trochet Delphine, Vaubourg Vanessa, Amiel Jeanne, Gallego Jorge, Brunet Jean-François, Goridis Christo
Abstract excerpt
Breathing is maintained and controlled by a network of neurons in the brainstem that generate respiratory rhythm and provide regulatory input. Central chemoreception, the mechanism for CO(2) detection that provides an essential stimulatory input, is thought to involve neurons located near the medullary surface, whose nature is controversial. Good candidates are serotonergic medullary neurons and glutamatergic...
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