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Article

Chemosensitivity of Phox2b-expressing retrotrapezoid neurons is mediated in part by input from 5-HT neurons.

The Journal of physiology - 1 May 2019

Wu Yuanming, Proch Katherine L, Teran Frida A, Lechtenberg Ryan J, Kothari Harsh, Richerson George B

Abstract excerpt

KEY POINTS: Neurons of the retrotrapezoid nucleus (RTN) and medullary serotonin (5-HT) neurons are both candidates for central CO2 /pH chemoreceptors, but it is not known how interactions between them influence their responses to pH. We found that RTN neurons in brain slices were stimulated by exogenous 5-HT and by heteroexchange release of endogenous 5-HT, and these responses were blocked by antagonists of 5-HT7...

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Identifiers

PMID: 30866045
DOI: 10.1113/JP277052
PMCID: PMC6826216

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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