Article

Automated image segmentation uncovers the role of CD74 <sup>high</sup> human microglia in cognitive decline

2025-08-30

Abstract excerpt

The role of activated microglia in Alzheimer’s disease (AD) is well established; the proportion of stage III activated microglia has been associated with AD and cognitive decline, but this morphologically defined subtype is relatively uncommon (1-2% of microglia) and its cellular function is unknown. Single-cell RNA-sequencing revealed CD74 as a marker gene that is enriched in immunologically active microglial sub...

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Literature Corpus work: e98cd563-59c9-5b7f-b94f-1124c655cbc8
DOI: 10.1101/2025.08.25.672200

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