Article

Hypoxia induces transcription of DOT1L in articular cartilage to protect against osteoarthritis

2021-05-15

Abstract excerpt

<h4>ABSTRACT</h4> Osteoarthritis is the most prevalent joint disease worldwide and a leading source of pain and disability. To date, this disease lacks curative treatment as underlying molecular mechanisms remain largely unknown. The histone methyltransferase DOT1L protects against osteoarthritis, and DOT1L-mediated H3K79 methylation is reduced in human and mouse osteoarthritic joints. Thus, restoring DOT1L funct...

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Literature Corpus work: e754cf2f-10bc-5936-aef9-619a0f0cebe9
DOI: 10.1101/2021.05.14.444225

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