Article
H3K36 methyltransferase NSD1 protects against osteoarthritis through regulating chondrocyte differentiation and cartilage homeostasis
2023-09-07
Abstract excerpt
<title>Abstract</title> <p>Osteoarthritis (OA) is the most common joint diseases, there are no disease-modifying drugs, and the pathological mechanisms of OA need further study. Here, we show that H3K36 methylations were decreased in senescent chondrocytes and age-induced osteoarthritic cartilage. Transgenic<italic> K36M/+; Prrx1-Cre </italic>mice showed articular cartilage destruction and osteophytes formation....
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Identifiers and source
- Literature Corpus work
- 6258271d-502f-57e7-8e2e-5ba896ac96e2
- DOI
- 10.21203/rs.3.rs-3270831/v1