Genome-wide association and functional studies identify the DOT1L gene to be involved in cartilage thickness and hip osteoarthritis.

doi:10.1073/pnas.1119899109

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Article

Genome-wide association and functional studies identify the DOT1L gene to be involved in cartilage thickness and hip osteoarthritis.

Proceedings of the National Academy of Sciences of the United States of America - 22 May 2012

Castaño Betancourt Martha C, Cailotto Frederic, Kerkhof Hanneke J, Cornelis Frederique M F, Doherty Sally A, Hart Deborah J, Hofman Albert, Luyten Frank P, Maciewicz Rose A, Mangino Massimo, Metrustry Sarah, Muir Kenneth, Peters Marjolein J, Rivadeneira Fernando, Wheeler Maggie, Zhang Weiya, Arden Nigel, Spector Tim D, Uitterlinden Andre G, Doherty Michael, Lories Rik J U, Valdes Ana M, van Meurs Joyce B J

Abstract excerpt

Hip osteoarthritis (HOA) is one of the most disabling and common joint disorders with a large genetic component that is, however, still ill-defined. To date, genome-wide association studies (GWAS) in osteoarthritis (OA) and specifically in HOA have yielded only few loci, which is partly explained by heterogeneity in the OA definition. Therefore, we here focused on radiographically measured joint-space width...

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Identifiers

PMID: 22566624
DOI: 10.1073/pnas.1119899109
PMCID: PMC3361426

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