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Article

Hypoxia induces DOT1L in articular cartilage to protect against osteoarthritis

2 Nov 2021

Abstract excerpt

Osteoarthritis is the most prevalent joint disease worldwide, and it is a leading source of pain and disability. To date, this disease lacks curative treatment, as underlying molecular mechanisms remain largely unknown. The histone methyltransferase DOT1L protects against osteoarthritis, and DOT1L-mediated H3K79 methylation is reduced in human and mouse osteoarthritic joints. Thus, restoring DOT1L function seems...

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PMID: 34727094
DOI: 10.1172/jci.insight.150451

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Related research

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Hypoxia induces DOT1L in articular cartilage to protect against osteoarthritisPMID 34727094Read ↗

Hypoxia induces transcription of DOT1L in articular cartilage to protect against osteoarthritisSemantic proximity Read ↗

DOT1L safeguards cartilage homeostasis and protects against osteoarthritisSemantic proximity Read ↗

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Transcriptome analysis in osteoarthritis primary tissues identifies high-confidence effector genesSemantic proximity Read ↗

H3K36 methyltransferase NSD1 protects against osteoarthritis through regulating chondrocyte differentiation and cartilage homeostasisSemantic proximity Read ↗

The effect of ITLN1, XCL2 and DOT1L variants on knee osteoarthritis risk in the Han population.Semantic proximity Read ↗

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Elucidating another level of epigenetic regulation in osteoarthritis by identifying functional <i>cis</i> -acting long non-coding RNAs and their targets in articular cartilageSemantic proximity Read ↗

The epigenetic enzyme DOT1L orchestrates vascular smooth muscle cell–monocyte crosstalk and protects against atherosclerosis via the NF-κB pathwaySemantic proximity Read ↗

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