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DOT1L safeguards cartilage homeostasis and protects against osteoarthritis

19 Jun 2017

Abstract excerpt

Osteoarthritis is the most prevalent and crippling joint disease, and lacks curative treatment, as the underlying molecular basis is unclear. Here, we show that DOT1L, an enzyme involved in histone methylation, is a master protector of cartilage health. Loss of DOT1L disrupts the molecular signature of healthy chondrocytes in vitro and causes osteoarthritis in mice. Mechanistically, the protective function of...

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PMID: 28627522
DOI: 10.1038/ncomms15889

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DOT1L safeguards cartilage homeostasis and protects against osteoarthritisPMID 28627522Read ↗

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