Article

Incorporating alternative Polygenic Risk Scores into the BOADICEA breast cancer risk prediction model

2022-07-09

Abstract excerpt

<h4>Background</h4> The multifactorial risk prediction model BOADICEA enables identification of women at higher or lower risk of developing breast cancer. BOADICEA models genetic susceptibility in terms of the effects of rare variants in breast cancer susceptibility genes and a polygenic component, decomposed into an unmeasured and a measured component - the polygenic risk score (PRS). The current version was deve...

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Literature Corpus work: e7390c20-64b1-5ce0-9bb9-a96bb5011ed2
DOI: 10.1101/2022.07.08.22276452

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