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Article

Prospective Evaluation of the Addition of Polygenic Risk Scores to Breast Cancer Risk Models.

JNCI cancer spectrum - 1 Jun 2021

Li Sherly X, Milne Roger L, Nguyen-Dumont Tu, Wang Xiaochuan, English Dallas R, Giles Graham G, Southey Melissa C, Antoniou Antonis C, Lee Andrew, Li Shuai, Winship Ingrid, Hopper John L, Terry Mary Beth, MacInnis Robert J

Abstract excerpt

Background: The Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm and the International Breast Cancer Intervention Study breast cancer risk models are used to provide advice on screening intervals and chemoprevention. We evaluated the performance of these models, which now incorporate polygenic risk scores (PRSs), using a prospective cohort study. Methods: We used a case-cohort...

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Identifiers

PMID: 33977228
DOI: 10.1093/jncics/pkab021
PMCID: PMC8099999

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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