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Article

Incorporating Alternative Polygenic Risk Scores into the BOADICEA Breast Cancer Risk Prediction Model.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 6 Mar 2023

Mavaddat Nasim, Ficorella Lorenzo, Carver Tim, Lee Andrew, Cunningham Alex P, Lush Michael, Dennis Joe, Tischkowitz Marc, Downes Kate, Hu Donglei, Hahnen Eric, Schmutzler Rita K, Stockley Tracy L, Downs Gregory S, Zhang Tong, Chiarelli Anna M, Bojesen Stig E, Liu Cong, Chung Wendy K, Pardo Monica, Feliubadaló Lidia, Balmaña Judith, Simard Jacques, Antoniou Antonis C, Easton Douglas F

Abstract excerpt

BACKGROUND: The multifactorial risk prediction model BOADICEA enables identification of women at higher or lower risk of developing breast cancer. BOADICEA models genetic susceptibility in terms of the effects of rare variants in breast cancer susceptibility genes and a polygenic component, decomposed into an unmeasured and a measured component - the polygenic risk score (PRS). The current version was developed...

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Identifiers

PMID: 36649146
DOI: 10.1158/1055-9965.EPI-22-0756
PMCID: PMC9986688

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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