Article
The BOADICEA model of genetic susceptibility to breast and ovarian cancers: updates and extensions.
British journal of cancer - 22 Apr 2008
Antoniou A C, Cunningham A P, Peto J, Evans D G, Lalloo F, Narod S A, Risch H A, Eyfjord J E, Hopper J L, Southey M C, Olsson H, Johannsson O, Borg A, Pasini B, Passini B, Radice P, Manoukian S, Eccles D M, Tang N, Olah E, Anton-Culver H, Warner E, Lubinski J, Gronwald J, Gorski B, Tryggvadottir L, Syrjakoski K, Kallioniemi O-P, Eerola H, Nevanlinna H, Pharoah P D P, Easton D F
Abstract excerpt
Multiple genetic loci confer susceptibility to breast and ovarian cancers. We have previously developed a model (BOADICEA) under which susceptibility to breast cancer is explained by mutations in BRCA1 and BRCA2, as well as by the joint multiplicative effects of many genes (polygenic component). We have now updated BOADICEA using additional family data from two UK population-based studies of breast cancer and...
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