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Article

BOADICEA: a comprehensive breast cancer risk prediction model incorporating genetic and nongenetic risk factors.

Genetics in medicine : official journal of the American College of Medical Genetics - 1 Aug 2019

Lee Andrew, Mavaddat Nasim, Wilcox Amber N, Cunningham Alex P, Carver Tim, Hartley Simon, Babb de Villiers Chantal, Izquierdo Angel, Simard Jacques, Schmidt Marjanka K, Walter Fiona M, Chatterjee Nilanjan, Garcia-Closas Montserrat, Tischkowitz Marc, Pharoah Paul, Easton Douglas F, Antoniou Antonis C

Abstract excerpt

PURPOSE: Breast cancer (BC) risk prediction allows systematic identification of individuals at highest and lowest risk. We extend the Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation Algorithm (BOADICEA) risk model to incorporate the effects of polygenic risk scores (PRS) and other risk factors (RFs). METHODS: BOADICEA incorporates the effects of truncating variants in BRCA1, BRCA2, PALB2,...

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Source

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Identifiers

PMID: 30643217
DOI: 10.1038/s41436-018-0406-9
PMCID: PMC6687499

Genes

ATM
BRCA1
BRCA2
CHEK2
PALB2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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BOADICEA: a comprehensive breast cancer risk prediction model incorporating genetic and nongenetic risk factors.PMID 30643217Read ↗

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Enhancing the BOADICEA cancer risk prediction model to incorporate new data on RAD51C, RAD51D, BARD1 updates to tumour pathology and cancer incidence.Semantic proximity Read ↗

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Enhancing the BOADICEA cancer risk prediction model to incorporate new data on <i>RAD51C, RAD51D, BARD1</i>, updates to tumour pathology and cancer incidencesSemantic proximity Read ↗

Clinical applicability of the Polygenic Risk Score for breast cancer risk prediction in familial cases.Semantic proximity Read ↗

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Genetic and Nongenetic Risk Factors for Breast Cancer Risk Estimation.Semantic proximity Read ↗

Polygenic Risk Scores for Breast Cancer: Modern Approaches to Risk Prediction and Subtype Identification.Semantic proximity Read ↗

Validation of the BOADICEA model and a 313-variant polygenic risk score for breast cancer risk prediction in a Dutch prospective cohort.Semantic proximity Read ↗

Ancestry-specific polygenic risk scores improve clinical assessments of breast cancer risk in diverse populationsSemantic proximity Read ↗

Validation of the BOADICEA model for predicting the likelihood of carrying pathogenic variants in eight breast and ovarian cancer susceptibility genesSemantic proximity Read ↗

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