Therapeutic relevance of the protein phosphatase 2A in cancer.

doi:10.18632/oncotarget.11399

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Article

Therapeutic relevance of the protein phosphatase 2A in cancer.

Oncotarget - 20 Sept 2016

Cunningham Chelsea E, Li Shuangshuang, Vizeacoumar Frederick S, Bhanumathy Kalpana Kalyanasundaram, Lee Joo Sang, Parameswaran Sreejit, Furber Levi, Abuhussein Omar, Paul James M, McDonald Megan, Templeton Shaina D, Shukla Hersh, El Zawily Amr M, Boyd Frederick, Alli Nezeka, Mousseau Darrell D, Geyer Ron, Bonham Keith, Anderson Deborah H, Yan Jiong, Yu-Lee Li-Yuan, Weaver Beth A, Uppalapati Maruti, Ruppin Eytan, Sablina Anna, Freywald Andrew, Vizeacoumar Franco J

Abstract excerpt

Chromosomal Instability (CIN) is regarded as a unifying feature of heterogeneous tumor populations, driving intratumoral heterogeneity. Polo-Like Kinase 1 (PLK1), a serine-threonine kinase that is often overexpressed across multiple tumor types, is one of the key regulators of CIN and is considered as a potential therapeutic target. However, targeting PLK1 has remained a challenge due to the off-target effects...

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Identifiers

PMID: 27557495
DOI: 10.18632/oncotarget.11399
PMCID: PMC5308671

Genes

PLK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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