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Microglia and CD206+ border-associated mouse macrophages maintain their embryonic origin during Alzheimer’s disease

5 Oct 2021

Abstract excerpt

Brain microglia and border-associated macrophages (BAMs) display distinct spatial, developmental, and phenotypic features. Although at steady state, the origins of distinct brain macrophages are well-documented, the dynamics of their replenishment in neurodegenerative disorders remain elusive, particularly for activated CD11c + microglia and BAMs. In this study, we conducted a comprehensive fate-mapping analysis...

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PMID: 34609281
DOI: 10.7554/elife.71879

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