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Insoluble Aβ overexpression in an <i>App</i> knock-in mouse model alters microstructure and gamma oscillations in the prefrontal cortex, and social and anxiety-related behaviours

2018-12-16

Abstract excerpt

We studied two new App knock-in mice models of Alzheimer’s disease ( App NL-F and App NL-G-F ), which generate elevated levels of Aβ 40 and Aβ 42 without the confounds associated with APP overexpression. This enabled us to assess changes in anxiety-related and social behaviours, and neural alterations potentially underlying such changes, driven specifically by Aβ accumulation. App NL-G-F knock-in mice exh...

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Literature Corpus work
e6feb358-1486-56d9-8cb6-f7ab9462f91f
DOI
10.1101/494443
Open publication

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Insoluble Aβ overexpression in an <i>App</i> knock-in mouse model alters microstructure and gamma oscillations in the prefrontal cortex, and social and anxiety-related behavioursDOI 10.1101/494443
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