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Generation of a hybrid <i>App</i> <sup>NL-G-F/NL-G-F</sup> × <i>Thy1</i> -GCaMP6s <sup>+/-</sup> Alzheimer disease mouse mitigates the behavioral and hippocampal encoding deficits of <i>APP</i> knock-in mutations of <i>App</i> <sup>NL-G-F/NL-G-F</sup> mice

2022-11-20

Abstract excerpt

<h4>ABSTRACT</h4> In contrast to most transgenic mouse models of Alzheimer disease (AD), knock-in mice expressing familial AD-linked mutations of the amyloid precursor protein ( App ) gene exhibit stereotypical age-dependent amyloid beta (Aβ) pathology and cognitive impairment without physiologically unrealistic App overexpression. This study investigated the effect of familial AD-linked App mutations on hippo...

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Literature Corpus work
d226fbfb-069a-5b07-a14c-664daecaa45a
DOI
10.1101/2022.11.18.517152
Open publication

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Generation of a hybrid <i>App</i> <sup>NL-G-F/NL-G-F</sup> × <i>Thy1</i> -GCaMP6s <sup>+/-</sup> Alzheimer disease mouse mitigates the behavioral and hippocampal encoding deficits of <i>APP</i> knock-in mutations of <i>App</i> <sup>NL-G-F/NL-G-F</sup> miceDOI 10.1101/2022.11.18.517152
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