Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cognitive deficits in single App knock-in mouse models

2 Jul 2016

Abstract excerpt

Transgenic mouse models of Alzheimer's disease (AD) with nonphysiologic overexpression of amyloid precursor protein (APP) exhibit various unnatural symptoms/dysfunctions. To overcome this issue, mice with single humanized App knock-in (KI) carrying Swedish (NL), Beyreuther/Iberian (F), and Arctic (G) mutations in different combinations were recently developed. The validity of these mouse models of AD from a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Computational Drug Discovery Methods
Share to Tryptophan and brain disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27377630
DOI: 10.1016/j.nlm.2016.07.001

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cognitive deficits in single App knock-in mouse modelsPMID 27377630Read ↗

Single App knock-in mouse models of Alzheimer's disease.Semantic proximity Read ↗

Longitudinal characterization reveals behavioral impairments in aged APP knock in mouse modelsSemantic proximity Read ↗

New mouse model of Alzheimer's.Semantic proximity Read ↗

Cognitive and emotional alterations in App knock-in mouse models of Aβ amyloidosisSemantic proximity Read ↗

Histological and Behavioral Phenotypes of a Novel Mutated APP Knock-In Mouse.Semantic proximity Read ↗

Updates on mouse models of Alzheimer’s diseaseSemantic proximity Read ↗

Behavioral phenotypes of amyloid-based genetically modified mouse models of Alzheimer's disease.Semantic proximity Read ↗

An App knock-in rat model for Alzheimer’s disease exhibiting Aβ and tau pathologies, neuronal death and cognitive impairmentsSemantic proximity Read ↗

An isogenic panel of App knock-in mouse models: Profiling β-secretase inhibition and endosomal abnormalitiesSemantic proximity Read ↗

Recent Advances in the Modeling of Alzheimer’s DiseaseSemantic proximity Read ↗

[Selected mice models based on APP, MAPT and presenilin gene mutations in research on the pathogenesis of Alzheimer's disease].Semantic proximity Read ↗

New <i>App</i> knock-in mice that accumulate wild-type human Aβ as rapidly as <i> App <sup>NL-G-F</sup> </i> mice exhibit intensive cored plaque pathology and neuroinflammationSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.