Article

FAM136A is an essential chaperone for mitochondrial membrane protein biogenesis

2026-08-04

Abstract excerpt

<h4>ABSTRACT</h4> The metabolic and signaling function of mitochondria rely on a network of chaperones within the inner membrane space (IMS) that regulate the biogenesis of nascent mitochondrial proteins. Using a genome wide CRISPRi screen we found that in human cells FAM136A is required for biogenesis of all three voltage-dependent anion channel (VDAC) paralogs, an abundant and essential family of β-barrel metab...

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Literature Corpus work: e6d7df72-6358-5de5-beed-2620b82838c3
DOI: 10.64898/2026.08.03.742567

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