Article

SLC25A46 is in contact with lysosomes and plays a role in mitochondrial cholesterol homeostasis

2024-04-01

Abstract excerpt

<h4>ABSTRACT</h4> Mitochondrial morphology reflects the dynamic equilibrium between fusion and fission events, controlled by cellular signaling. A cytoprotective response known as stress-induced mitochondrial hyperfusion (SIMH) is triggered by nutrient starvation and we show that the outer mitochondrial membrane protein SLC25A46 is required for this response. To unravel the cellular mechanisms involved, we conduc...

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Literature Corpus work: 8e61ac13-1621-51ff-9fd7-af5ba8379a10
DOI: 10.1101/2024.04.01.587618

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