Article
Msp1 Is a Membrane Protein Dislocase for Tail-Anchored Proteins.
Molecular cell - 20 Jul 2017
Wohlever Matthew L, Mateja Agnieszka, McGilvray Philip T, Day Kasey J, Keenan Robert J
Abstract excerpt
Mislocalized tail-anchored (TA) proteins of the outer mitochondrial membrane are cleared by a newly identified quality control pathway involving the conserved eukaryotic protein Msp1 (ATAD1 in humans). Msp1 is a transmembrane AAA-ATPase, but its role in TA protein clearance is not known. Here, using purified components reconstituted into proteoliposomes, we show that Msp1 is both necessary and sufficient to drive...
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