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Article

Discovery of a pre-mRNA structural scaffold as a contributor to the mammalian splicing code.

Nucleic acids research - 9 Jul 2021

Saha Kaushik, Fernandez Mike Minh, Biswas Tapan, Joseph Simpson, Ghosh Gourisankar

Abstract excerpt

The specific recognition of splice signals at or near exon-intron junctions is not explained by their weak conservation and instead is postulated to require a multitude of features embedded in the pre-mRNA strand. We explored the possibility of 3D structural scaffold of AdML-a model pre-mRNA substrate-guiding early spliceosomal components to the splice signal sequences. We find that mutations in the non-cognate...

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Source

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Identifiers

PMID: 34161584
DOI: 10.1093/nar/gkab533
PMCID: PMC8266590

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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