Article
Analysis of splicing parameters in the dystrophin gene: relevance for physiological and pathogenetic splicing mechanisms.
Human genetics - 1 Jul 2001
Sironi M, Pozzoli U, Cagliani R, Comi G P, Bardoni A, Bresolin N
Abstract excerpt
The molecular mechanisms that direct splice-site selection and assure orderly exon juxtaposition have not been fully clarified. The extraordinary nature of the dystrophin gene points to several hurdles in the processing of transcripts. In this study, dystrophin statistical and thermodynamic splicing parameters have been evaluated providing the first comprehensive description for a single human gene. We show that...
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