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Article

Control of 3' splice site selection in S. cerevisiae by a highly conserved amino acid within the Prp8 α-finger domain.

RNA (New York, N.Y.) - 16 Dec 2025

Liu Ye, Paulson Joshua C, Hoskins Aaron A

Abstract excerpt

Precise recognition of the boundaries between exons and introns (splice sites [SS]) is essential for the fidelity of gene expression. In contrast with the 5'SS, the consensus 3'SS sequence in both Saccharomyces cerevisiae and humans is just three nucleotides long: YAG. How the correct 3'SS is chosen among many possible alternates by the spliceosome is often unclear but likely involves proofreading by the Prp22...

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Identifiers

PMID: 41167814
DOI: 10.1261/rna.080642.125
PMCID: PMC12707134

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Control of 3' splice site selection in S. cerevisiae by a highly conserved amino acid within the Prp8 α-finger domain.PMID 41167814Read ↗

Control of 3’ Splice Site Selection in <i>S. cerevisiae</i> by a Highly Conserved Amino Acid within the Prp8 α-finger DomainSemantic proximity Read ↗

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