Article

Cell-autonomous differentiation of human primed embryonic stem cells into trophoblastic syncytia through the nascent amnion-like cell state

2021-06-28

Abstract excerpt

<h4>Summery</h4> Human primed embryonic stem cells (pESCs) are known to be converted to cells with several trophoblast properties, but it has remained controversial whether this phenomenon represents the inherent differentiation competence of human pESCs to trophoblast lineages. In this study, we report that chemical blockage of ACTIVIN/NODAL and FGF signals is sufficient to steer human pESCs into GATA3-expressin...

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Literature Corpus work: 65cc574b-03cc-5ee0-b044-e12983381e2b
DOI: 10.1101/2021.06.28.450118

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