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Efficient derivation of human trophoblast stem cells from primed pluripotent stem cells

11 Aug 2021

Abstract excerpt

Human trophoblast stem cells (hTSCs) provide a valuable model to study placental development and function. While primary hTSCs have been derived from embryos/early placenta, and transdifferentiated hTSCs from naïve human pluripotent stem cells (hPSCs), the generation of hTSCs from primed PSCs is problematic. We report the successful generation of TSCs from primed hPSCs and show that BMP4 substantially enhances...

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PMID: 34380613
DOI: 10.1126/sciadv.abf4416

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