Pooled CRISPRi screening reveals fungal-specific vulnerabilities across environments and genetic backgrounds

Abstract excerpt

<title>Abstract</title> <p>The rising rate of drug-resistant fungal infections and the emergence of fungal pathogens with intrinsic resistance phenotypes are a growing concern. The close evolutionary distance between mammals and fungi complicates the design of new antifungals and increases the chances of toxic off-target effects. As such, antifungal drug development usually focuses on fungal-specific proteins whe...

Topics

Open a Topic to create a Post that cites this publication.

• Antifungal resistance and susceptibility
• Candida albicans
• Clustered Regularly Interspaced Short Palindromic Repeats
• CRISPR and Genetic Engineering
• CRISPR-Cas Systems
• Phenotype
• RNA, Guide, CRISPR-Cas Systems
• Saccharomyces cerevisiae

Identifiers and source

Literature Corpus work

1d611343-30cc-5e05-baa2-b90287174bb1

DOI

10.21203/rs.3.rs-8554844/v1