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Development and applications of a CRISPR activation system for facile genetic overexpression in Candida albicans

30 Nov 2022

Abstract excerpt

For the fungal pathogen Candida albicans, genetic overexpression readily occurs via a diversity of genomic alterations, such as aneuploidy and gain-of-function mutations, with important consequences for host adaptation, virulence, and evolution of antifungal drug resistance. Given the important role of overexpression on C. albicans biology, it is critical to develop and harness tools that enable the analysis of...

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PMID: 36450451
DOI: 10.1093/g3journal/jkac301

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