Article
Pooled CRISPRi screening reveals fungal-specific vulnerabilities across environments and genetic backgrounds
2025-12-22
Abstract excerpt
The rising rate of drug-resistant fungal infections and the emergence of fungal pathogens with intrinsic resistance phenotypes are a growing concern. The close evolutionary distance between mammals and fungi complicates the design of new antifungals and increases the chances of toxic off-target effects. As such, antifungal drug development usually focuses on fungal-specific proteins when considering potential new...
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Identifiers and source
- Literature Corpus work
- 7e5e647f-47ce-54a5-903b-c04a32847d9d
- DOI
- 10.64898/2025.12.19.695556