Article
A Candida albicans CRISPR system permits genetic engineering of essential genes and gene families.
Science advances - 1 Jan 2015
Vyas Valmik K, Barrasa M Inmaculada, Fink Gerald R
Abstract excerpt
Candida albicans is a pathogenic yeast that causes mucosal and systematic infections with high mortality. The absence of facile molecular genetics has been a major impediment to analysis of pathogenesis. The lack of meiosis coupled with the absence of plasmids makes genetic engineering cumbersome, especially for essential functions and gene families. We describe a C. albicans CRISPR system that overcomes many of...
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